|Application ||IHC, IF, FC|
|Other Accession||4583, 315|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Mucin-2, MUC-2, Intestinal mucin-2, MUC2, SMUC|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||MUC2 (Mucin 2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.|
|Cellular Location||Secreted. Note=In the intestine, secreted into the inner and outer mucus layers.|
|Tissue Location||Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder|
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Provided below are standard protocols that you may find useful for product applications.
Recognizes a single glycoprotein of 520kDa, identified as mucin 2 (MUC2). This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC3. Mucins are high molecular weight glycoproteins, which constitute the major component of the mucus layer that protects the gastric epithelium.ĀMUC2 is specifically expressed in goblet cells of the small intestine & colon; in about 65% of colonic carcinomas and about 40% of gastric carcinomas. MUC2 is rarely expressed outside of the GI tract with the exceptions of mucinous carcinoma of breast and clear cell-type carcinomas of the ovary.
Gum, J.R., et al. 1992. The human Mucin 2 intestinal mucin has cysteine- rich subdomains located both upstream and downstream of its central repetitive region. J. Biol. Chem. 267: 21375-21383. |
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