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MUC3 (Mucin 3) Antibody

Mouse Monoclonal Antibody [Clone MUC3/1154 ]

     
  • IHC -  MUC3 (Mucin 3) Antibody AH11896-7
    Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC3 Monoclonal Antibody (MUC3/1154).
  • IHC -  MUC3 (Mucin 3) Antibody AH11896-7
    Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC3 Monoclonal Antibody (MUC3/1154).
  • IHC -  MUC3 (Mucin 3) Antibody AH11896-7
    Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with MUC3 Monoclonal Antibody (MUC3/1154).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession Q02505
Other Accession 4584, 57876, 744422, 744530, Q9H195
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names MUC3/1154
Calculated MW 1100kDa
Additional Information
Gene ID 4584
Other Names Mucin-3A, MUC-3A, Intestinal mucin-3A, MUC3A, MUC3
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions MUC3 (Mucin 3) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MUC3A (HGNC:7513)
Function Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.
Cellular Location Isoform 1: Membrane; Single-pass membrane protein Isoform 3: Secreted Isoform 5: Secreted.
Tissue Location Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.
Research Areas
Citations (0)

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Background

It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.

References

Gum, J.R. Jr., et al. 1990. Molecular cloning of cDNAs derived from a novel human intestinal Mucin gene. Biochem. Biophys. Res. Commun 171: 407-415. |

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$ 324.00
Cat# AH11896-7
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