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MUC6 (Mucin 6 / Gastric Mucin) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone MUC6/916 ]

     
  • IHC -  MUC6 (Mucin 6 / Gastric Mucin) Antibody - With BSA and Azide AH11929-20
    Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC6 Monoclonal Antibody (MUC6/916).
    detail
  • IHC -  MUC6 (Mucin 6 / Gastric Mucin) Antibody - With BSA and Azide AH11929-20
    Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC6 Monoclonal Antibody (MUC6/916).
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, FC
Primary Accession Q6W4X9
Other Accession 4588, 528432
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names MUC6/916
Calculated MW 252kDa
Additional Information
Gene ID 4588
Other Names Mucin-6, MUC-6, Gastric mucin-6, MUC6
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions MUC6 (Mucin 6 / Gastric Mucin) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MUC6
Function May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
Cellular Location Secreted.
Tissue Location Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
Research Areas
Citations (0)
citation

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Background

The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.

References

Bartman A E, Buisine M P, Aubert J P, et al.. The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues. J. Pathol. 186(4):398-405 (1998). |

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$ 219.00
$ 499.00
Cat# AH11929-20
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