CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody
Mouse Monoclonal Antibody [Clone 123A8; same 56C04 ]
|Application ||IHC, IF|
|Other Accession||4684, 503878, P13592|
|Isotype||Mouse / IgG1, kappa|
|Clone Names||123A8; same 56C04|
|Calculated MW||180, 145 and 125kDa|
|Other Names||Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56, NCAM1, NCAM|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Lipid-anchor, GPI- anchor Isoform 5: Secreted.|
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Provided below are standard protocols that you may find useful for product applications.
This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
Gerardy-Schahn R; et. al. Int Journal of Cancer. Supplement, 1994, 8:38-42. | Michalides R; et. al. International Journal of Cancer. Supplement, 1994, 8:34-7. | K. Moolenaar et al.Cancer Research 50, 1102-1106, 1990 | Schol DJ; et. al. Int J Cancer. Supplement, 1988, 2:34-4
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