NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Antibody
Mouse Monoclonal Antibody [Clone SPM299 ]
|Application ||IHC, IF, FC|
|Other Accession||4804, 415768, 681726|
|Reactivity||Human, Rabbit, Monkey, Baboon, Cat|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
Marano N, et. al. Journal of Neurochemistry, 1987, 48:225-32. |
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