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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >    NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody   

NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody

Mouse Monoclonal Antibody [Clone SPM564 ]

  • IHC -  NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody AH12018
    Formalin-fixed paraffin-embedded human Ewing�s sarcoma stained with NKX2.2 Monoclonal Antibody (SPM564).
  • IHC -  NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody AH12018
    Formalin-fixed paraffin-embedded human Pancreas stained with NKX2.2 Monoclonal Antibody (SPM564).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95096
Other Accession 4821, 516922
Reactivity Human, Mouse, Chicken
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names SPM564
Calculated MW 40-50kDa
Additional Information
Gene ID 4821
Other Names Homeobox protein Nkx-2.2, Homeobox protein NK-2 homolog B, NKX2-2, NKX2.2, NKX2B
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKX2-2
Synonyms NKX2.2, NKX2B
Function Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Research Areas
Citations (0)

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Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.


Wang, Y.C. et al. (2009) Endocr Relat Cancer 16, 267-79. | Yoshida A et. al. Am J Surg Pathol. 2012;36(7):993-9

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$ 324.00
Cat# AH12018
(40 western blots)
Availability: 2-3 days
Bulk Size
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