|Application ||WB, IHC, IF, FC|
|Other Accession||4953, 467701|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Ornithine decarboxylase, ODC, 22.214.171.124, ODC1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Ornithine Decarboxylase-1 (ODC-1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.|
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Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
Schipper RG; Rutten RG; Sauerbeck M; Schielen WJ; Adams PJ; Kopitz J; Bohley P; Tesser GI; Verhofstad AA. Preparation and characterization of monoclonal antibodies against ornithine decarboxylase. Journal of Immunological Methods, 1993, 161(2):205-15. |
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