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PAX7 (Rhabdomyosarcoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM613 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC |
|---|---|
| Primary Accession | P23759 |
| Other Accession | 5081, 113253 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | SPM613 |
| Calculated MW | 57kDa |
| Gene ID | 5081 |
|---|---|
| Other Names | Paired box protein Pax-7, HuP1, PAX7, HUP1 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | PAX7 (Rhabdomyosarcoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX7 |
|---|---|
| Synonyms | HUP1 |
| Function | Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P47239}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).
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