PAX7 (Rhabdomyosarcoma Marker) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone SPM613 ]
|Other Accession||5081, 113253|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Paired box protein Pax-7, HuP1, PAX7, HUP1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||PAX7 (Rhabdomyosarcoma Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.|
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The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).
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