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PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Antibody

Mouse Monoclonal Antibody [Clone PCNA/694 ]

  • WB -  PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Antibody AH12049
    Western Blot Analysis of HepG2 Cell Lysate using PCNA Monoclonal Antibody (PCNA/694)
  • IHC -  PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Antibody AH12049
    Formalin-fixed, paraffin-embedded human Tonsil stained with PCNA Monoclonal Antibody (PCNA/694)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12004
Other Accession 5111, 147433, 728886
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names PCNA/694
Calculated MW 36kDa
Additional Information
Gene ID 5111
Other Names Proliferating cell nuclear antigen, PCNA, Cyclin, PCNA
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Cellular Location Nucleus. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Research Areas
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Recognizes a non-histone protein of 36kDa, which is identified as proliferating cell nuclear antigen (PCNA). It is also known as cyclin or polymerase delta auxiliary protein. Elevated expression of PCNA/cyclin has been shown in the nucleus during late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases. This MAb is excellent for multiple applications.


Waseem NH & Lane DP. 1990. J Cell Sci. 96:121-9. | Hall PA et al. 1990. J. Pathol. 162(4):285-94

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$ 324.00
Cat# AH12049
(40 western blots)
Availability: 2-3 days
Bulk Size
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