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PD1 / PDCD1 / CD279 (Programmed Cell Death 1) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone PDCD1/922 ]

     
  • IHC -  PD1 / PDCD1 / CD279 (Programmed Cell Death 1) Antibody - With BSA and Azide AH12053-20
    Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) Monoclonal Antibody (PDCD1/922).
    detail
  • IHC -  PD1 / PDCD1 / CD279 (Programmed Cell Death 1) Antibody - With BSA and Azide AH12053-20
    Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) Monoclonal Antibody (PDCD1/922).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession Q15116
Other Accession 5133, 158297
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names PDCD1/922
Calculated MW 55kDa
Additional Information
Gene ID 5133
Other Names Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions PD1 / PDCD1 / CD279 (Programmed Cell Death 1) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCD1 {ECO:0000303|PubMed:7851902, ECO:0000312|HGNC:HGNC:8760}
Function Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)
citation

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Background

PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

References

Ishida, Y., et al. 1992. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11: 3887-3895. |

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$ 219.00
$ 499.00
Cat# AH12053-20
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