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Progesterone Receptor (Marker of Progestin Dependence) Antibody

Mouse Monoclonal Antibody [Clone PR484 ]

  • IHC -  Progesterone Receptor (Marker of Progestin Dependence) Antibody AH12077
    Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Progesterone Receptor Ab (PR484).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06401
Other Accession 5241, 2905
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names PR484
Calculated MW PR-A (81kDa) and PR-B (116kDa).
Additional Information
Gene ID 5241
Other Names Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Progesterone Receptor (Marker of Progestin Dependence) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PGR
Synonyms NR3C3
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Cellular Location Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane
Research Areas
Citations (0)

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This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.


Press M, et al. Steroids. 2002 Aug; 67(9):799-813. | Mote P, et al. J Clin Pathol., 2001; 54: 624-630

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$ 324.00
Cat# AH12077
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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