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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Cytochrome C (Mitochondrial Marker) Antibody   

Cytochrome C (Mitochondrial Marker) Antibody

Mouse Monoclonal Antibody [Clone SPM389 ]

  • IHC -  Cytochrome C (Mitochondrial Marker) Antibody AH12095
    Formalin-fixed, paraffin-embedded human Salivary Tumor stained with Cytochrome C Monoclonal Antibody (SPM389).
  • IHC -  Cytochrome C (Mitochondrial Marker) Antibody AH12095
    Formalin-fixed, paraffin-embedded human Pancreas stained with Cytochrome C Monoclonal Antibody (SPM389).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P99999
Other Accession 54205, 437060
Reactivity Human, Mouse, Rat, Horse, Dog
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names SPM389
Calculated MW 15kDa
Additional Information
Gene ID 54205
Other Names Cytochrome c, CYCS, CYC
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cytochrome C (Mitochondrial Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CYC
Function Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Cellular Location Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane
Research Areas
Citations (0)

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It recognizes an epitope within amino acids 93-104 of pigeon Cytochrome C, a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).


Goshorn SG, E Retzel, and R Jemmerson. Common Structural Features among Monoclonal Antibodies Binding the Same Antigenic Region of Cytochrome c. J Biol Chem 266:2134-2142 (1991). |

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$ 324.00
Cat# AH12095
(40 western blots)
Availability: 2-3 days
Bulk Size
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