UGT1A9 (Hepatocyte & Hepatocellular Carcinoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone UGT1A9/1229 ]
|Application ||IF, FC|
|Other Accession||54600, 554822|
|Isotype||Mouse / IgG2b, kappa|
|Other Names||UDP-glucuronosyltransferase 1-9, UDPGT 1-9, UGT1*9, UGT1-09, UGT1.9, 126.96.36.199, UDP-glucuronosyltransferase 1-I, UGT-1I, UGT1I, UDP-glucuronosyltransferase 1A9, lugP4, UGT1A9, GNT1, UGT1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||UGT1A9 (Hepatocyte & Hepatocellular Carcinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.|
|Cellular Location||Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine|
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It recognizes a protein of about 60kDa, which is identified as human UGT1A9. It does not cross-react with the other UGT1A isoforms including UGT1A7, UGT1A8, and UGT1A10 and shows a high degree of specificity. UGT1A9 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This MAb binds to human hepatocytes and the majority of human hepatocellular carcinomas (HCC s). In frozen sections, it stains hepatic cells and may be used as a marker of the liver. This MAb also binds to cell preparations of hepatocellular carcinoma biopsies or cell lines.
Shingo Oda, Miki Nakajima, Masahiko Hatakeyama, Tatsuki Fukami, and Tsuyoshi Yokoi. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. Drug Metabolism and Disposition, 40:1620-1627, 2012
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