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UACA / Nucling (Nuclear Membrane Marker) Antibody

Mouse Monoclonal Antibody [Clone UACA/1222 ]

  • WB -  UACA / Nucling (Nuclear Membrane Marker) Antibody AH12112
    Western Blot of A549 Cell Lysate using UACA / Nucling Monoclonal Antibody (UACA/1222)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BZF9
Other Accession 55075, 108049
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names UACA/1222
Calculated MW 160kDa
Additional Information
Gene ID 55075
Other Names Uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA, KIAA1561
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions UACA / Nucling (Nuclear Membrane Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1561
Function Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Expressed diffusely in cytoplasm
Tissue Location Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
Research Areas
Citations (0)

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UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.


Yamada, K., et al. 2001. Identification of a novel autoantigen UACA in patients with panuveitis. Biochem. Biophys. Res. Commun. 280: 1169-1176. | Ohkura, T., et al. 2004. Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves disease. Biochem. Biophys. Res. Commun. 321: 432-440

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$ 324.00
Cat# AH12112
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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