DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody
Mouse Monoclonal Antibody [Clone DG1/447 ]
|Application ||IHC, IF, FC|
|Other Accession||55107, 503074|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1, DOG1, ORAOV2, TAOS2, TMEM16A|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DOG1, ORAOV2, TAOS2, TMEM16A|
|Function||Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.|
|Tissue Location||Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles|
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Provided below are standard protocols that you may find useful for product applications.
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
Espinosa I, et. al. Am J Surg Pathol 2008;32:210-218
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