|Application ||IHC, IF, FC|
|Other Accession||5618, 368587|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Prolactin receptor, PRL-R, PRLR|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Prolactin Receptor (hPRL-Receptor) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in breast, placenta, kidney, liver and pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.
Br J Cancer. 2011;104(10):1641-8. | Breast Cancer Res. 2008;10(4):R68. | Histopathology. 2008;53(1):56-61. | Mod Pathol. 2010;23(7):961-71. | Breast Cancer Res Treat. 2011;128(1):31-40
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.