Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone 246-E9.E7; same as HLA.ABC.m2 ]
|Application ||IF, FC|
|Other Accession||567, 534255|
|Isotype||Mouse / IgG2a, kappa|
|Clone Names||246-E9.E7; same as HLA.ABC.m2|
|Other Names||Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.|
|Cellular Location||Secreted. Note=Detected in serum and urine|
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Recognizes a protein of 12kDa, identified as β-microglobulin. β-microglobulin non-covalently associates with the 44kDa chain to form the HLA Class I antigen complex. Human β-2 microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. This MAb is specific to human β-2 microglobulin and does not react with non-human primate cells. This antibody reacts with all cell types excluding erythrocytes. The detection of β-2 microglobulin in body fluids has been used as a tumor marker and for monitoring patients with HIV infection.
Sparrow RL. Human cell surface antigens defined by monoclonal antibodies. PhD thesis, University of Melbourne, 1983. | Betts RL, McKenzie IFC: Monoclonal antibodies to the major histocompatibility antigens. Monoclonal hybridoma antibodies: Techniques and applications. Edited by D. Hurrel. Uniscience series program. C.R.C. Press, Cleveland, OH: 1983, pp. 193-222 | Brodsky FM, Parham P. Barnstable CJ, Crumpton MJ, Bodmer WF: Monoclonal antibodies for analysis of the HLA system. lmmunol Rev 47:3, (1979). | Leah J. Cosgrove et al.: HLA (Class I) antigens on platelets are involved in platelet function. Immunol. Cell Biol., 66 (1) 69-77 (1988
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