Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody
Mouse Monoclonal Antibody [Clone SPM617 ]
|Application ||IHC, IF, FC|
|Other Accession||567, 534255|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.|
|Cellular Location||Secreted. Note=Detected in serum and urine|
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Beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
Liabeuf A, le Borgne de Kaouel C, Kourilsky FM, Malissen B, Manuel Y, Sanderson AR. An antigenic determinant of human beta 2-microglobulin masked by the association with HLA heavy chains at the cell surface: analysis using monoclonal antibodies. J Immunol. 1981 Oct;127(4):1542-8. |
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