Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody
Mouse Monoclonal Antibody [Clone B2M/961 ]
|Application ||IHC, IF, FC|
|Other Accession||567, 534255|
|Isotype||Mouse / IgG2b, kappa|
|Other Names||Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.|
|Cellular Location||Secreted. Note=Detected in serum and urine|
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Provided below are standard protocols that you may find useful for product applications.
Recognizes a protein of 12kDa, identified as β-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Josson, S., et al. 2011. β2-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res. 71: 2600-2610. |
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