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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >    CD45RB (B-Cell Marker) Antibody   

CD45RB (B-Cell Marker) Antibody

Mouse Monoclonal Antibody [Clone PD7/26 ]

  • IHC -  CD45RB (B-Cell Marker) Antibody AH12198
    Formalin-fixed, paraffin-embedded human Tonsil stained with CD45RB Ab (PD7/26).
  • IHC -  CD45RB (B-Cell Marker) Antibody AH12198
    Formalin-fixed, paraffin-embedded human Tonsil stained with CD45RB Ab (PD7/26).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08575
Other Accession 5788, 654514
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names PD7/26
Calculated MW 180-220kDa
Additional Information
Gene ID 5788
Other Names Receptor-type tyrosine-protein phosphatase C,, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD45RB (B-Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD45
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Research Areas
Citations (0)

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CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.


Gatter KC et. al. Lancet, 1985 Jun 8, 1(8441):1302-5. | Michie SA et. al. American Journal of Clinical Pathology, 1987, 88(4):457-62

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$ 324.00
Cat# AH12198
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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