|Application ||IHC, IF, FC|
|Other Accession||5788, 654514|
|Isotype||Mouse / IgG1, kappa|
|Clone Names||BRA-11; same as BRA-11G|
|Other Names||Receptor-type tyrosine-protein phosphatase C, 184.108.40.206, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD45RB (B-Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts|
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Provided below are standard protocols that you may find useful for product applications.
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin.
Sedlak et al. Neoplasma 1989: 643, 1989. | Sutherland et.al Int. Immunol., 14(8): 953 – 962 (August 1, 2002) | Lim et.al Int. Immunol., 18(2):291-300 (2006
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