Actin, Smooth Muscle (Leiomyosarcoma Marker) Antibody
Mouse Monoclonal Antibody [Clone 1A4; same as asm-1 ]
|Application ||IHC, IF, FC|
|Other Accession||59, 500483|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Pig, Chicken, Goat, Baboon, Cow, Sheep, Guinea Pig, Dog, Cat|
|Isotype||Mouse / IgG2a, kappa|
|Clone Names||1A4; same as asm-1|
|Other Names||Actin, aortic smooth muscle, Alpha-actin-2, Cell growth-inhibiting gene 46 protein, ACTA2, ACTSA, ACTVS|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Actin, Smooth Muscle (Leiomyosarcoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Actin is a major component of the cytoskeleton and is present in most cell types. This MAb is highly specific to actin from smooth muscles. Its epitope lies in the first four N-terminal amino acids. This MAb does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. This antibody could be used together with anti-muscle specific actin and myogenin in making a diagnosis of smooth muscle and skeletal muscle tumors. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.
Skalli O et. al. Journal of Cell Biology, 1986, 103:2787-96. |
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