Actin, Smooth Muscle (Leiomyosarcoma Marker) Antibody
Mouse Monoclonal Antibody [Clone 1A4 + ACTA2/791 ]
|Application ||IHC, IF, FC|
|Other Accession||59, 500483|
|Isotype||Mouse / IgG's|
|Clone Names||1A4 + ACTA2/791|
|Other Names||Actin, aortic smooth muscle, Alpha-actin-2, Cell growth-inhibiting gene 46 protein, ACTA2, ACTSA, ACTVS|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Actin, Smooth Muscle (Leiomyosarcoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Actin is a major component of the cytoskeleton and is present in most cell types. It is highly specific to actin from smooth muscles. This MAb does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. This antibody could be used together with anti-muscle specific actin and myogenin in making a diagnosis of smooth muscle and skeletal muscle tumors. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.
Gown, A.M., et al. 1985. A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes. J. Cell Biol. 100: 807-813. |
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