|Application ||IHC, IF|
|Other Accession||5947, 5948, 5950, 529571, P09455, P50120|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Goat, Chimpanzee|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Retinol Binding Protein-1 (RBP1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.|
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Provided below are standard protocols that you may find useful for product applications.
This MAb recognizes an epitope within the 74-182 C-terminal sequence (11kD peptide fragment) of human serum Cellular Retinol Binding Protein 1 (CRBP 1), a single-chain glycoprotein belonging to the superfamily of hydrophobic molecule transporter proteins, which is responsible for transport of retinol (vitamin A1) from the liver to peripheral target tissues, like the eye, where it mediates the cellular uptake. CRBP 1 is synthesized by hepatic parenchymal cells where it becomes bound to its ligand retinol and is then released into the circulation, where it binds further to the protein transthyretin, to form a transporting complex, which is big enough not to be lost by filtration through the kidney glomeruli. It is detected in nearly all tissues with higher expression in adult ovary, pancreas, pituitary gland, adrenal gland, and fetal liver.
Reddy BM; Karande AA; Adiga PR. Antigenic determinants of human serum retinol binding protein as probed with monoclonal antibodies. Molecular Immunology, 1993, 30(15):1355-60. | Reddy B. et al.: Biochem. Int. 21, 367-376 (1990). | Reddy B. et al.: Molec. Immunol. 29, 511-516 (1992). |
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