|Application ||IHC, IF|
|Other Accession||5947, 5948, 5950, 529571, P09455, P50120|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Goat|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Retinol Binding Protein-1 (RBP1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.|
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Provided below are standard protocols that you may find useful for product applications.
Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein-1 (RBP1). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein post-transnationally and results in defective delivery and supply to the epidermal cells.
Naylor, H.M., et al. 1999. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy-terminus of RBP. Biochemistry 38: 2647-2653
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