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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody   

Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody

Mouse Monoclonal Antibody [Clone SPM530 ]

  • IHC -  Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody AH12245
    Formalin-fixed, paraffin-embedded human non-Hodgkin's Lymphoma stained with Bcl-2 Monoclonal Antibody (SPM530).
  • FC -  Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody AH12245
    Flow Cytometry of Jurkat cells using Bcl-2 Monoclonal Antibody (SPM530) (red) and isotype control (green).
  • WB -  Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody AH12245
    Western Blot of Bcl-2 in human Skin using Bcl-2 Monoclonal Antibody (SPM530).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10415
Other Accession 596, 150749
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM530
Calculated MW 25-26kDa
Additional Information
Gene ID 596
Other Names Apoptosis regulator Bcl-2, BCL2
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.


Pezzella F et. al.. American Journal of Pathology, 1990, 137(2):225-32

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$ 324.00
Cat# AH12245
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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