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S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone S100A1/1012 ]

  • IHC -  S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide AH12277-100
    Formalin-fixed, paraffin-embedded human Melanoma stained with S100A1 Monoclonal Antibody (S100A1/1012).
  • IHC -  S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide AH12277-100
    Formalin-fixed, paraffin-embedded human Schwanoma stained with S100A1 Monoclonal Antibody (S100A1/1012).
  • IF -  S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide AH12277-100
    Confocal Immunofluorescent analysis of A2058 cellsusing AF488-labeled S100A1 Monoclonal Antibody (S100A1/1012) (Green).F-actin filaments were labeled with DyLight 554 Phalloidin (red).DAPI was used to stain the cell nuclei (blue).
  • IF -  S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide AH12277-100
    Confocal Immunofluorescent analysis of A2058 cells using AF488-labeled Isotype Control Monoclonal Antibody (IgG2a) (Green). F-actin filaments were labeled with DyLight 554 Phalloidin (red). DAPI was used to stain the cell nuclei (blue). (Negative Control)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23297
Other Accession 6271, 515715
Reactivity Human, Mouse, Rat, Cow
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names S100A1/1012
Calculated MW 10-12kDa
Additional Information
Gene ID 6271
Other Names Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100A1, S100A
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions S100A1 (Astrocyte Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name S100A1
Synonyms S100A
Function Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Cellular Location Cytoplasm.
Tissue Location Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain
Research Areas
Citations (0)

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The family of EF-hand type Ca2+-binding proteins includes calbindin, S-100 alpha and beta, calgranulins, B and C, and the parvalbumin family members, including parvalbumin alpha and parvalbumin beta. The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 alpha chain and S-100 beta chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of two alpha chains, two beta chains or one alpha and one beta chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwann s cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 alpha and beta are present in a variety of other tissues and calbindin is present in intestine and kidney.


Heizmann, C.W. 1988. Calcium-binding proteins of the EF-type. J. Cardiovasc. Pharmacol. 5: S30-S37. |

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$ 354.00
$ 484.00
Cat# AH12277-100
Availability: 2-3 days
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