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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Sex Hormone Binding Globulin (SHBG) Antibody   

Sex Hormone Binding Globulin (SHBG) Antibody

Mouse Monoclonal Antibody [Clone SPM605 ]

     
  • IHC -  Sex Hormone Binding Globulin (SHBG) Antibody AH12301
    Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with SHBG Monoclonal Antibody (SPM605)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession P04278
Other Accession 6462, 632235
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1
Clone Names SPM605
Calculated MW 45kDa
Additional Information
Gene ID 6462
Other Names Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Sex Hormone Binding Globulin (SHBG) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHBG
Function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Cellular Location Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis
Tissue Location Isoform 1 and isoform 2 are present in liver and testis
Research Areas
Citations (0)

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Background

Recognizes a protein of 45kDa, identified as SHBG. It functions as an androgen transport protein, but may also be involved in receptor-mediated processes. Each dimer binds one molecule of steroid. It is specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

References

Grishkovskaya, I., et al. 2000. Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain. EMBO. J. 19: 504-512. |

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$ 324.00
Cat# AH12301
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