Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Fascin-1 (Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide   

Fascin-1 (Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone FSCN1/417 ]

  • IHC -  Fascin-1 (Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide AH12330
    Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with Fascin-1 Monoclonal Antibody (FSCN1/417)
  • IHC -  Fascin-1 (Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide AH12330
    Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with Fascin-1 Monoclonal Antibody (FSCN1/417)
  • IHC -  Fascin-1 (Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide AH12330
    Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Fascin-1 Monoclonal Antibody (FSCN1/417)
  • WB -  Fascin-1 (Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide AH12330
    Western Blot of HeLa Cell Lysate using Fascin-1 Monoclonal Antibody (FSN1/417)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16658
Other Accession 6624, 118400
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names FSCN1/417
Calculated MW 55kDa
Additional Information
Gene ID 6624
Other Names Fascin, 55 kDa actin-bundling protein, Singed-like protein, p55, FSCN1, FAN1, HSN, SNL
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Fascin-1 (Reed-Sternberg Cell Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FSCN1
Synonyms FAN1, HSN, SNL
Function Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
Cellular Location Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol
Tissue Location Ubiquitous.
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkinā€™s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.


Yamashiro-Matsumura S and Matsumura F. J Biol Chem 1985; 260(8): 5087. | Yamashro-Matsumura S and Matsumura F. J Cell Biol 1986; 103:631. | Duh F-M, et al. DNA Cell Biol 1994; 13(8):821

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

$ 354.00
$ 484.00
Cat# AH12330
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanKoreaLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Santa Cruz Alternative
Terms & Conditions