|Application ||WB, IHC, IF, FC|
|Other Accession||6624, 118400|
|Isotype||Mouse / IgG2a, kappa|
|Other Names||Fascin, 55 kDa actin-bundling protein, Singed-like protein, p55, FSCN1, FAN1, HSN, SNL|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Fascin-1 (Reed-Sternberg Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAN1, HSN, SNL|
|Function||Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol|
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Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Yamashiro-Matsumura S and Matsumura F. J Biol Chem 1985; 260(8): 5087. | Yamashro-Matsumura S and Matsumura F. J Cell Biol 1986; 103:631. | Duh F-M, et al. DNA Cell Biol 1994; 13(8):821. |
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