|Application ||WB, IHC, IF, FC|
|Other Accession||6663, 376984|
|Isotype||Mouse / IgG2b, kappa|
|Clone Names||SOX10/991 + SOX10/1074|
|Other Names||Transcription factor SOX-10, SOX10|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||SOX10 (Melanoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity).|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed in fetal brain and in adult brain, heart, small intestine and colon|
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Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Mohamed A, et al. SOX10 Expression in malignant melanoma, carcinoma, and normal tissues. Appl Immunohistochem Mol Morphol. 2013; 21(6):506-10.�
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