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Mouse Monoclonal Antibody [Clone 84-3C1 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P16150 |
| Other Accession | 6693, 632188 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | 84-3C1 |
| Calculated MW | 95, 115, or 135kDa |
| Gene ID | 6693 |
|---|---|
| Other Names | Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD43 (T-Cell Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPN |
|---|---|
| Synonyms | CD43 |
| Function | One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas |
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Provided below are standard protocols that you may find useful for product applications.
Background
It recognizes a cell surface glycoprotein of 95/115/135kDa (depending upon the extent of glycosylation), identified as CD43 (Workshop III). 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.
References
Cobbold S. et. al. Leucocyte Typing III, (ed. McMichael AJ et. al.), Oxford Univ. Press, p789-803, 1987
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