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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Transgelin (SM22-alpha) Antibody   

Transgelin (SM22-alpha) Antibody

Mouse Monoclonal Antibody [Clone TAGLN/247 ]

  • IHC -  Transgelin (SM22-alpha) Antibody AH12371
    Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Transgelin Monoclonal Antibody (TAGLN/247)
  • IHC -  Transgelin (SM22-alpha) Antibody AH12371
    Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Transgelin Monoclonal Antibody (TAGLN/247)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01995
Other Accession 6876, 410977
Reactivity Human, Mouse, Rabbit, Pig, Cow
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names TAGLN/247
Calculated MW 22kDa
Additional Information
Gene ID 6876
Other Names Transgelin, 22 kDa actin-binding protein, Protein WS3-10, Smooth muscle protein 22-alpha, SM22-alpha, TAGLN, SM22, WS3-10
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Transgelin (SM22-alpha) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SM22, WS3-10
Function Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.


Shapland, C., et al. 1993. Purification and properties of transgelin: a transformation and shape change sensitive Actin-gelling protein. J. Cell Biol. 121: 1065-1073

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$ 324.00
Cat# AH12371
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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