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Mouse Monoclonal Antibody [Clone 2H11 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, FC |
|---|---|
| Primary Accession | P01266 |
| Other Accession | 7038, 654591 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | 2H11 |
| Calculated MW | 660kDa (Dimeric Form) |
| Gene ID | 7038 |
|---|---|
| Other Names | Thyroglobulin, Tg, TG |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Thyroglobulin (Thyroidal Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TG |
|---|---|
| Function | Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). |
| Cellular Location | Secreted. |
| Tissue Location | Thyroid gland specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAb 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. ĀThe vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
References
Ossendorp FA, et. al. Journal of Immunological Methods, 1989, 120(2):191-200. | Bellet, D, et al. J Clin Endocrin Metab 1983;56:530-533 | Moll. Cell. Endocrinol 66: 199205 (1989). | Endocrinol. 127: 419430 (1990). |
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