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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Thyroglobulin (Thyroidal Cell Marker) Antibody   

Thyroglobulin (Thyroidal Cell Marker) Antibody

Mouse Monoclonal Antibody [Clone SPM221 ]

  • IHC -  Thyroglobulin (Thyroidal Cell Marker) Antibody AH12390
    Formalin-fixed, paraffin-embedded human Thyroid Carcinoma stained with Thyroglobulin Monoclonal Antibody (SPM221).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01266
Other Accession 7038, 654591
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM221
Calculated MW 660kDa (Dimeric Form)
Additional Information
Gene ID 7038
Other Names Thyroglobulin, Tg, TG
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Thyroglobulin (Thyroidal Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TG
Function Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Cellular Location Secreted.
Tissue Location Thyroid gland specific.
Research Areas
Citations (0)

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Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. ĀPrior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. ĀThe vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.


Ossendorp FA, et. al. Journal of Immunological Methods, 1989, 120(2):191-200. | Bellet, D, et al. J Clin Endocrin Metab 1983;56:530-533 | Heffess CS et al. Cancer. 2002;95(9):1869-78 | Judkins AR et al. Hum Pathol. 1999;30(11):1373-

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$ 324.00
Cat# AH12390
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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