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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Transglutaminase II (TGM2) Antibody   

Transglutaminase II (TGM2) Antibody

Mouse Monoclonal Antibody [Clone TGM2/419 ]

  • IHC -  Transglutaminase II (TGM2) Antibody AH12407
    Formalin-fixed, paraffin-embedded human Tonsil stained with Transglutaminase II Monoclonal Antibody (TGM2/419)
  • IHC -  Transglutaminase II (TGM2) Antibody AH12407
    Formalin-fixed, paraffin-embedded human Placenta stained with Transglutaminase II Monoclonal Antibody (TGM2/419)
  • IHC -  Transglutaminase II (TGM2) Antibody AH12407
    Formalin-fixed, paraffin-embedded human Uterus stained with Transglutaminase II Monoclonal Antibody (TGM2/419)
  • IHC -  Transglutaminase II (TGM2) Antibody AH12407
    Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with Transglutaminase II Monoclonal Antibody (TGM2/419)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21980
Other Accession 7052, 517033
Reactivity Human, Mouse, Rat, Rabbit, Monkey
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names TGM2/419
Calculated MW 77-85kDa
Additional Information
Gene ID 7052
Other Names Protein-glutamine gamma-glutamyltransferase 2,, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Transglutaminase II (TGM2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGM2
Function Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Research Areas
Citations (0)

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Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.


Yamanishi, K., et al. 1991. Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture. Biochem. Biophys. Res. Commun. 175: 906-913. |

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$ 324.00
Cat# AH12407
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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