|Application ||IHC, IF, FC|
|Other Accession||7298, 369762|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Thymidylate synthase, TS, TSase, 126.96.36.199, TYMS, TS|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Thymidylate Synthase (5-FU Resistance Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.|
|Cellular Location||Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane|
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Provided below are standard protocols that you may find useful for product applications.
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 188.8.131.52). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Johnston PG, et. al. Cancer Research, 1991, 51(24):6668-76. | Johnston PG, et. al. Cancer Research, 1992, 52(16):4306-12
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