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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >    Thymidylate Synthase (5-FU Resistance Marker) Antibody   

Thymidylate Synthase (5-FU Resistance Marker) Antibody

Mouse Monoclonal Antibody [Clone TMS715 ]

  • IHC -  Thymidylate Synthase (5-FU Resistance Marker) Antibody AH12471
    Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Thymidylate Synthase Monoclonal Antibody (TMS715).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04818
Other Accession 7298, 369762
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names TMS715
Calculated MW 36kDa
Additional Information
Gene ID 7298
Other Names Thymidylate synthase, TS, TSase,, TYMS, TS
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Thymidylate Synthase (5-FU Resistance Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TS
Function Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Cellular Location Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane
Research Areas
Citations (0)

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It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.


Johnston PG, et. al. Journal of the National Cancer Institute, 1997, 89(4):308-13. | Pestalozzi BC, et. al. Journal of Clinical Oncology, 1997, 15(5):1923-31

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$ 324.00
Cat# AH12471
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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