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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody   

Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody

Mouse Monoclonal Antibody [Clone SPM611 ]

  • IHC -  Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody AH12484
    Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Monoclonal Antibody (SPM611)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17643
Other Accession 7306, 270279
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names SPM611
Calculated MW 75kDa
Additional Information
Gene ID 7306
Other Names 5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, 1.14.18.-, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TYRP1
Synonyms CAS2, TYRP, TYRRP
Function Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
Cellular Location Melanosome membrane; Single- pass type I membrane protein. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity).
Tissue Location Pigment cells.
Research Areas
Citations (0)

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It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.ĀRecent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.


Orlow, S.J., et al. 1994. High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. J. Invest. Dermatol. 103: 196-201. |

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$ 324.00
Cat# AH12484
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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