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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Renal Cell Carcinoma / gp200 Antibody   

Renal Cell Carcinoma / gp200 Antibody

Mouse Monoclonal Antibody [Clone SPM487 ]

  • IHC -  Renal Cell Carcinoma / gp200 Antibody AH12549
    Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with RCC Monoclonal Antibody (SPM487).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16790
Other Accession 768, 63287
Reactivity Human, Horse
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names SPM487
Calculated MW 200kDa
Additional Information
Gene ID 768
Other Names Carbonic anhydrase 9,, Carbonate dehydratase IX, Carbonic anhydrase IX, CA-IX, CAIX, Membrane antigen MN, P54/58N, Renal cell carcinoma-associated antigen G250, RCC-associated antigen G250, pMW1, CA9, G250, MN
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Renal Cell Carcinoma / gp200 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CA9
Synonyms G250, MN
Function Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Cellular Location Nucleus. Nucleus, nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus
Tissue Location Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa
Research Areas
Citations (0)

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Recognizes a glycoprotein of ~200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.


Yoshida SO, et. al. Cancer Research, 1989, 49(7):1802-9

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$ 324.00
Cat# AH12549
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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