p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) Antibody
Rabbit Polyclonal Antibody [Clone ]
|Application ||WB, IHC-P, IF, FC|
|Other Accession||8626, 137569|
|Reactivity||Human, Mouse, Rat, Cow|
|Isotype||Rabbit / IgG|
|Other Names||Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KET, P63, P73H, P73L, TP73L|
|Function||Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.|
|Tissue Location||Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues|
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Provided below are standard protocols that you may find useful for product applications.
p40 (p63 delta) is a marker recently determined to be highly specific for squamous basal cells in the immunohistochemistry (IHC) application. The current more routinely recommended marker, p63, appears to have less specificity compared to p40, especially on squamous cell tumors. The ability to differentiate between lung adenocarcinoma vs. squamous cell carcinoma is difficult and has bearing on the different therapeutic avenues for each subtype treatment. p63 antibodyā€™s ability to distinguish between the tumor types appears to be inferior when compared to p40. The ability to utilize an antibody probe for p40 as a squamous cell marker bolsters its use for future sub-classification of lung cancers, especially by immunohistochemical techniques.
Bishop, JA et. al. Modern Pathology 25 : 405–4152. Scagliotti G et. al. J Thorac Oncol 6:64–70. 3. Kargi A et. al. Appl Immunohistochem Mol Morphol 15:415–420
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