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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >    Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide   

Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM619 ]

  • IHC -  Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide AH12577
    Formalin-fixed, paraffin-embedded human Tonsil stained with Cyclin B1 Monoclonal Antibody (SPM619)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14635
Other Accession 891, 23960
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM619
Calculated MW 55-62kDa
Additional Information
Gene ID 891
Other Names G2/mitotic-specific cyclin-B1, CCNB1, CCNB
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNB1
Synonyms CCNB
Function Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Research Areas
Citations (0)

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It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.


Galaktionov, K. and Beach D. 1991. Specific activation of Cdc25 tyrosine phosphatases by B type cyclins: Evidence for multiple roles of mitotic cyclins. Cell 67: 1181-1194. |

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$ 124.00
$ 324.00
$ 454.00
Cat# AH12577
(40 western blots)
Availability: 2-3 days
Bulk Size
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