|Application ||IF, FC|
|Other Accession||916, 3003|
|Isotype||Mouse / IgG1, kappa|
|Other Names||T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD3 (T-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Reacts with five invariable CD3 chains (designated as and ) with molecular weight ranging from 16-28kDa. CD3 is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly Intracytoplasmic. The CD3 complex is closely associated at the lymphocyte cell surface with T cell antigen receptor (TCR) and is involved in transducing antigen-recognition signals into cytoplasm of T cells and in regulating the cell surface expression of the TCR complex.
Kishimoto T. et al., eds. Leukocyte Typing VI, p44-48 and p1111, Garland Publishing, Inc, New York and London, 1997.Meuer SC et al. Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature 1983, 303(5920):808-810 | Reinherz et al., Cell 30, 715, (1982) | Borst et al., J. Biol. Chem. 258, 5135, (1983) | Van den Elsen et al., Nature 312, (1984) | Furley et al., Cell 46, 75, (1986) | Gold et al., Nature 321, 4, (1986) | Oettgen and Terhorst, Hum. Immunol. 18, 187, (1987) | Clevers et al., Ann. Rev. Immunol. 6, 629, (1988
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