CD4 (T-Helper/Inducer Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone EDU-2 ]
|Application ||IF, FC|
|Other Accession||920, 631659|
|Isotype||Mouse / IgG2a, kappa|
|Other Names||T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, CD4|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD4 (T-Helper/Inducer Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum|
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Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.ĀThis MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.
Reinberz EL et al. eds. Leykcocyte Typing II, Springer-Verlag, Berlin, 1985. | Knapp W. et. al. (eds) Leukocyte Typing IV, p314-330, Oxford University Press, Oxford, 1989.Sattentau QJ, et al. The CD4 antigen: physiological ligand and HIV receptor. Cell. 1988, 52(5):631-633. | Gaubin M, et al. Molecular basis of T lymphocyte CD4 antigen functions. Eur J Clin Chem Clin Biochem. 1996, 34(9):723-728.Mazerolles F, et al. Down regulation of T-cell adhesion by CD4. Hum Immunol. 1991, 31(1):40-6
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