|Application ||IHC, IF, FC|
|Other Accession||921, 58685|
|Reactivity||Human, Rat, Rabbit, Cow|
|Isotype||Mouse / IgG's|
|Clone Names||C5/473 + CD5/54/F6|
|Other Names||T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, CD5, CD5, LEU1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD5 (Mantle Cell Lymphoma Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a receptor in regulating T-cell proliferation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.
Ferry JA et. al. American Journal of Clinical Pathology, 1996, 105(1):31-7. | Gagneten D et. al. Diagnostic Cytopathology, 1996, 14(1):32-7
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.