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>   home   >   Products   >   Primary Antibodies   >   Immunology   >    CD7 (T-Cell Leukemia Marker) Antibody - With BSA and Azide   

CD7 (T-Cell Leukemia Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone B-F12 ]

     
  • SPECIFICATION
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, FC
Primary Accession P09564
Other Accession 924, 186820
Reactivity Human, Pig, Guinea Pig
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names B-F12
Calculated MW 40kDa
Additional Information
Other Names T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41, CD7, CD7
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD7 (T-Cell Leukemia Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD7
Function Not yet known.
Cellular Location Membrane; Single-pass type I membrane protein EMBL; X06180; CAA29546.1; -; mRNA EMBL; M37271; AAA51953.1; -; Genomic_DNA EMBL; BT006696; AAP35342.1; -; mRNA EMBL; BC009293; AAH09293.1; -; mRNA EMBL; BC013297; AAH13297.1; -; mRNA EMBL; D00749; BAA00646.1; -; Genomic_DNA CCDS; CCDS11807.1; - PIR; A39016; A39016 RefSeq; NP_006128.1; NM_006137.6 UniGene; Hs.36972; - ProteinModelPortal; P09564; - SMR; P09564; - BioGrid; 107362; 8 IntAct; P09564; 5 MINT; P09564; - STRING; 9606.ENSP00000312027; - iPTMnet; P09564; - PhosphoSitePlus; P09564; - SwissPalm; P09564; - BioMuta; CD7; - DMDM; 116031; - PaxDb; P09564; - PeptideAtlas; P09564; - PRIDE; P09564; - ProteomicsDB; 52247; - DNASU; 924; - Ensembl; ENST00000312648; ENSP00000312027; ENSG00000173762 GeneID; 924; - KEGG; hsa:924; - CTD; 924; - DisGeNET; 924; - EuPathDB; HostDB:ENSG00000173762.7; - GeneCards; CD7; - HGNC; HGNC:1695; CD7 HPA; CAB002594; - HPA; HPA039079; - MIM; 186820; gene neXtProt; NX_P09564; - OpenTargets; ENSG00000173762; - PharmGKB; PA26234; - eggNOG; ENOG410IYNZ; Eukaryota eggNOG; ENOG41117EQ; LUCA GeneTree; ENSGT00390000013965; - HOGENOM; HOG000285979; - HOVERGEN; HBG005290; - InParanoid; P09564; - KO; K06457; - OMA; YEDMSHS; - OrthoDB; EOG091G0Q1Y; - PhylomeDB; P09564; - TreeFam; TF338565; - SignaLink; P09564; - GeneWiki; CD7; - GenomeRNAi; 924; - PRO; PR:P09564; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000173762; - CleanEx; HS_CD7; - ExpressionAtlas; P09564; baseline and differential Genevisible; P09564; HS GO; GO:0016021; C:integral component of membrane; TAS:UniProtKB GO; GO:0016020; C:membrane; TAS:ProtInc GO; GO:0005886; C:plasma membrane; TAS:ProtInc GO; GO:0038023; F:signaling receptor activity; TAS:UniProtKB GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW GO; GO:0006955; P:immune response; TAS:UniProtKB GO; GO:0042110; P:T cell activation; TAS:UniProtKB GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB Gene3D; 2.60.40.10; -; 1 InterPro; IPR039090; CD7 InterPro; IPR007110; Ig-like_dom InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold InterPro; IPR003599; Ig_sub InterPro; IPR013106; Ig_V-set PANTHER; PTHR15343; PTHR15343; 1 Pfam; PF07686; V-set; 1 SMART; SM00409; IG; 1 SMART; SM00406; IGv; 1 SUPFAM; SSF48726; SSF48726; 1 PROSITE; PS50835; IG_LIKE; 1 1: Evidence at protein level; Adaptive immunity; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 25 CHAIN 26 240 T-cell antigen CD7 /FTId=PRO_0000014633 TOPO_DOM 26 180 Extracellular TRANSMEM 181 201 Helical. TOPO_DOM 202 240 Cytoplasmic DOMAIN 26 130 Ig-like REPEAT 145 153 1 REPEAT 154 162 2 REPEAT 163 171 3 REPEAT 172 180 4 REGION 145 180 4 X 9 AA tandem repeats, potential spacer function LIPID 198 198 S-palmitoyl cysteine CARBOHYD 45 45 N-linked (GlcNAc...) asparagine CARBOHYD 96 96 N-linked (GlcNAc...) asparagine DISULFID 35 142 {ECO:0000255|PROSITE-ProRule:PRU00114} DISULFID 48 114 {ECO:0000255|PROSITE-ProRule:PRU00114} VARIANT 113 113 T -> A (in dbSNP:rs34579511) /FTId=VAR_049855 SEQUENCE 240 AA; 25409 MW; EBBCE08279552108 CRC64; MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ
Research Areas
Citations (0)

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Background

Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

References

Knapp W et al. eds. Leukocyte typing IV, p341, Oxford University Press, Oxford, 1989.2. Miwa H, et al biological characteristics of CD7(+) acute leukemia. Leuk Lymphoma. 1996;21:239-44. 3. Rabinowich H, et al. J. Immunol. 1994 153(8):3504-3513.4. Emara M, et al. A human suppressor T-cell factor that inhibits T-cell replication by interaction with the IgM-Fc receptor (CD7). Hum Immunol. 1989;25(2):87-102.5. Thurlow PJ, A monoclonal antibody detecting a new human T cell antigen, HuLy-m2. Transplantation 1984, 38(2):143-147.6. Saxena A, et al. Biologic and clinical significance of CD7 expression in acute myeloid leukemia. Am J Hematol. 1998;58(4):278-84

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Cat# AH12623-20
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