CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone BU88 ]
|Application ||IF, FC|
|Other Accession||926, 405667|
|Isotype||Mouse / IgG1, kappa|
|Other Names||T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Cell membrane; Single-pass type I membrane protein Isoform 7: Secreted.|
|Tissue Location||Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
The T cell receptor (TCR) is a heterodimer composed of either Ī � and Ī � or Ī � and Ī � chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD8 (also designated Leu 2 or T8), a cell surface glycoprotein, is a two chain complex (Ī �-Ī � or Ī �-Ī �) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.
Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, 1989 | Parnes JR, CD4 and CD8 in T cell lineage commitment: alterations induced by expression of a CD8/CD4 chimeric transgene. HYPERLINK /htbin-post/Entrez/query?uid=8000031&form=6&db=m&Dopt=bSemin Immunol 1994, 6:221-229
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