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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >    CD14 (Monocyte / Macrophage Marker) Antibody - With BSA and Azide   

CD14 (Monocyte / Macrophage Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone LPSR/654 ]

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08571
Other Accession 929, 163867
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names LPSR/654
Calculated MW 55kDa
Additional Information
Gene ID 929
Other Names Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14, Monocyte differentiation antigen CD14, urinary form, Monocyte differentiation antigen CD14, membrane-bound form, CD14
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD14 (Monocyte / Macrophage Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD14
Function In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Location Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages
Research Areas
Citations (0)

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Recognizes a protein of 55kDa, identified as CD14 (also known lipopolysaccharide receptor). CD14 is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation.


Simmons, D.L., et al. 1989. Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood 73: 284-289. | Schumann, R.R. 1992. Function of lipopolysaccharide (LPS)-binding protein (LBP) and CD14, the receptor for LPS/LBP complexes: a short review. Res. Immunol. 143: 11-15

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$ 124.00
$ 324.00
$ 454.00
Cat# AH12649
(40 western blots)
Availability: 2-3 days
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