|Application ||IHC, IF, FC|
|Other Accession||931, 712553|
|Isotype||Mouse / IgG2a, kappa|
|Other Names||B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD20, MS4A1, CD20|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD20 / MS4A1 (B-Cell Marker) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein may be involved in the regulation of B-cell activation and proliferation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor|
|Tissue Location||Expressed on B-cells.|
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Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.
Tedder, T.F., et al. 1994. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol. Today 15: 450-454
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